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dc.contributor.authorTvete, Ingunn Fride
dc.contributor.authorKlemp, Marianne
dc.date.accessioned2023-03-03T15:09:39Z
dc.date.available2023-03-03T15:09:39Z
dc.date.created2022-02-07T21:26:44Z
dc.date.issued2022
dc.identifier.citationClinical Parkinsonism & Related Disorders. 2022, 6:100136 1-6.en_US
dc.identifier.issn2590-1125
dc.identifier.urihttps://hdl.handle.net/11250/3055833
dc.description.abstractObjectives We compared Monoamine oxidase B (MAO-B) – and dopamine agonist (DA) monotherapy patients with respect to survival, considering gender, age, first prescriber’s specialty and relevant co-morbidity, and compared their specialist health care contacts and hospitalizations. Methods With data from health registries, we considered 21,047 patients without redemptions for MAO-B, DA or levodopa 6 months prior to their first MAO-B or DA redemption in 2006 and followed them throughout 2016. We considered Cox proportional hazard regression models for comparing the risk of death among MAO-B and DA monotherapy patients. Results MAO-B-users had a higher mortality than DA-users, [HR: 1.587, 95% CI: 1.056; 2.384] for patients under 74 years. There was an increased mortality risk with increasing age, women had lower risk than men and previous diabetes-, antihypertensive-, and cardiac drug users had higher risk compared to patients without such history. Previous use of hypothyroid drugs and having a specialist as first prescriber were not significant risk factors. Among patients without hospitalizations 13.7% died, while among patients who spent at least one night in hospital 36.73% died. The median duration of a hospitalization among those who died and not were 17.5 and 7 days. Among the small proportion with specialist health care contacts circulatory- and respiratory-system diseases were the most frequent cause of contact. Conclusions DAs were most frequently given when initiating Parkinson’s treatment. DA-users had a lower mortality risk compared to MAO-B-users and less specialist health care contact.
dc.language.isoengen_US
dc.rightsNavngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/deed.no*
dc.titleParkinson’s disease, treatment choice and survival over timeen_US
dc.title.alternativeParkinson’s disease, treatment choice and survival over timeen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersion
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1016/j.prdoa.2022.100136
dc.identifier.cristin1998795
dc.source.journalClinical Parkinsonism & Related Disordersen_US
dc.source.volume6:100136en_US
dc.source.pagenumber1-6en_US


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Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal